Article
Crypt density and recruited enhancers underlie intestinal tumour initiation.
Nature - 1 Apr 2025
Gaynor Liam, Singh Harshabad, Tie Guodong, Badarinath Krithika, Madha Shariq, Mancini Andrew, Bhattacharya Swarnabh, Hoshino Mikio, de Sauvage Frederic J, Murata Kazutaka, Jadhav Unmesh, Shivdasani Ramesh A
Abstract excerpt
Oncogenic mutations that drive colorectal cancer can be present in healthy intestines for long periods without overt consequence1,2. Mutation of Apc, the most common initiating event in conventional adenomas3, activates Wnt signalling, thus conferring fitness on mutant intestinal stem cells (ISCs)4,5. Apc mutations may occur in ISCs that arise by routine self-renewal or by dedifferentiation of their progeny....
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