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Article

Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention.

Carcinogenesis - 1 Jan 2014

Fischer Jared M, Schepers Arnout G, Clevers Hans, Shibata Darryl, Liskay R Michael

Abstract excerpt

Although Apc mutation is widely considered an initiating event in colorectal cancer, little is known about the earliest stages of tumorigenesis following sporadic Apc loss. Therefore, we have utilized a novel mouse model that facilitates the sporadic inactivation of Apc via frameshift reversion of Cre in single, isolated cells and subsequently tracks the fates of Apc-deficient intestinal cells. Our results...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23996931
DOI: 10.1093/carcin/bgt296
PMCID: PMC3871938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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