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Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells

7 Mar 2022

Abstract excerpt

Recent data establish a logarithmic expansion of leucine rich repeat containing G protein coupled receptor 5-positive (Lgr5+) colonic epithelial stem cells (CESCs) in human colorectal cancer (CRC). Complementary studies using the murine 2-stage azoxymethane-dextran sulfate sodium (AOM-DSS) colitis-associated tumor model indicate early acquisition of Wnt pathway mutations drives CESC expansion during adenoma...

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PMID: 35260534
DOI: 10.1172/jci.insight.153793

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