Article
Apc-mutant cells act as supercompetitors in intestinal tumour initiation.
Nature - 1 Jun 2021
van Neerven Sanne M, de Groot Nina E, Nijman Lisanne E, Scicluna Brendon P, van Driel Milou S, Lecca Maria C, Warmerdam Daniël O, Kakkar Vaishali, Moreno Leandro F, Vieira Braga Felipe A, Sanches Delano R, Ramesh Prashanthi, Ten Hoorn Sanne, Aelvoet Arthur S, van Boxel Marouska F, Koens Lianne, Krawczyk Przemek M, Koster Jan, Dekker Evelien, Medema Jan Paul, Winton Douglas J, Bijlsma Maarten F, Morrissey Edward, Léveillé Nicolas, Vermeulen Louis
Abstract excerpt
A delicate equilibrium of WNT agonists and antagonists in the intestinal stem cell (ISC) niche is critical to maintaining the ISC compartment, as it accommodates the rapid renewal of the gut lining. Disruption of this balance by mutations in the tumour suppressor gene APC, which are found in approximately 80% of all human colon cancers, leads to unrestrained activation of the WNT pathway1,2. It has previously...
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