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Article

Inferring clonal evolution of tumors from single nucleotide somatic mutations.

BMC bioinformatics - 1 Feb 2014

Jiao Wei, Vembu Shankar, Deshwar Amit G, Stein Lincoln, Morris Quaid

Abstract excerpt

BACKGROUND: High-throughput sequencing allows the detection and quantification of frequencies of somatic single nucleotide variants (SNV) in heterogeneous tumor cell populations. In some cases, the evolutionary history and population frequency of the subclonal lineages of tumor cells present in the sample can be reconstructed from these SNV frequency measurements. But automated methods to do this reconstruction...

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PMID: 24484323
DOI: 10.1186/1471-2105-15-35
PMCID: PMC3922638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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