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Article

Bassoon contributes to tau-seed propagation and neurotoxicity

7 Nov 2022

Abstract excerpt

Tau aggregation is a defining histopathological feature of Alzheimer's disease and other tauopathies. However, the cellular mechanisms involved in tau propagation remain unclear. Here, we performed an unbiased quantitative proteomic study to identify proteins that specifically interact with this tau seed. We identified Bassoon (BSN), a presynaptic scaffolding protein, as an interactor of the tau seed isolated...

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PMID: 36344699
DOI: 10.1038/s41593-022-01191-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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