Fault-Tolerance Study on a Positive-Charged Cleft in 18S rRNA Methyltransferase DIMT1.

Abstract excerpt

Dimethyladenosine transferase 1 (DIMT1) is an RNA N6,6-dimethyladenosine (m26,6A) methyltransferase. DIMT1's role in pre-rRNA processing and ribosome biogenesis is critical for cell proliferation. Here, we investigated the minimal number of residues in a positively charged cleft on DIMT1 required for cell proliferation. We demonstrate that a minimum of four residues in the positively charged cleft must be mutated...

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