Article
Nucleic acid-binding properties of the RRM-containing protein RDM1.
Biochemical and biophysical research communications - 26 May 2006
Hamimes Samia, Bourgeon Dominique, Stasiak Alicja Z, Stasiak Andrzej, Van Dyck Eric
Abstract excerpt
RDM1 (RAD52 Motif 1) is a vertebrate protein involved in the cellular response to the anti-cancer drug cisplatin. In addition to an RNA recognition motif, RDM1 contains a small amino acid motif, named RD motif, which it shares with the recombination and repair protein, RAD52. RDM1 binds to single- and double-stranded DNA, and recognizes DNA distortions induced by cisplatin adducts in vitro. Here, we have...
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