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Article

Sequence-structure-function relationships of Tgs1, the yeast snRNA/snoRNA cap hypermethylase.

Nucleic acids research - 15 Aug 2003

Mouaikel John, Bujnicki Janusz M, Tazi Jamal, Bordonné Rémy

Abstract excerpt

The Saccharomyces cerevisiae Tgs1 methyltransferase (MTase) is responsible for conversion of the m(7)G caps of snRNAs and snoRNAs to a 2,2,7- trimethylguanosine structure. To learn more about the evolutionary origin of Tgs1 and to identify structural features required for its activity, we performed a structure-function study. By using sequence comparison and phylogenetic analysis, we found that Tgs1 shows...

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Identifiers

PMID: 12907733
DOI: 10.1093/nar/gkg656
PMCID: PMC169889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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