Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1

4 Feb 2015

Abstract excerpt

The function of RNA is subtly modulated by post-transcriptional modifications. Here, we report an important crosstalk in the covalent modification of two classes of RNAs. We demonstrate that yeast Kre33 and human NAT10 are RNA cytosine acetyltransferases with, surprisingly, specificity toward both 18S rRNA and tRNAs. tRNA acetylation requires the intervention of a specific and conserved adaptor: yeast Tan1/human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Peptidase Inhibition and Analysis
Share to RNA and protein synthesis mechanisms
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25653167
DOI: 10.1093/nar/gkv075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1PMID 25653167Read ↗

Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolutionSemantic proximity Read ↗

Activity reconstitution of Kre33 and Tan1 reveals a molecular ruler mechanism in eukaryotic tRNA acetylation.Semantic proximity Read ↗

Research progress on NAT10-mediated acetylation in normal development and diseaseSemantic proximity Read ↗

Antisense pairing and SNORD13 structure guide RNA cytidine acetylationSemantic proximity Read ↗

Modify or die?--RNA modification defects in metazoans.Semantic proximity Read ↗

THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder.Semantic proximity Read ↗

Human NOP2/NSUN1 Regulates Ribosome Biogenesis Through Non-Catalytic Complex Formation with Box C/D snoRNPsSemantic proximity Read ↗

Emerging role of RNA acetylation modification ac4C in diseases: Current advances and future challengesSemantic proximity Read ↗

Emerging role of N-acetyltransferase 10 in diseases: RNA ac4C modification and beyondSemantic proximity Read ↗

The Saccharomyces cerevisiae TAN1 gene is required for N4-acetylcytidine formation in tRNA.Semantic proximity Read ↗

Identification of a role for histone H2B ubiquitylation in noncoding RNA 3'-end formation through mutational analysis of Rtf1 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Initiator tRNA lacking 1-methyladenosine is unexpectedly targeted by the rapid tRNA decay pathway in evolutionarily distant yeast speciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.