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Article

Improved genotype inference reveals cis- and trans-driven variation in the loss-of-heterozygosity rates in yeast.

Genetics - 4 Apr 2026

Overton Michael S, Kryazhimskiy Sergey

Abstract excerpt

Loss-of-heterozygosity (LOH) events are an important source of genetic variation in diploids and are implicated in cancer. LOH-event rates vary across the genome and across genetic backgrounds, but our understanding of this variation is incomplete. State-of-the-art measurements of LOH rates are obtained from mutation accumulation (MA) experiments in heterozygous hybrids, mainly in yeast Saccharomyces cerevisiae....

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Identifiers

PMID: 41428366
DOI: 10.1093/genetics/iyaf274
PMCID: PMC13050209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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