Article

Genome-wide identification of loss of heterozygosity generated by mitotic homologous recombination reveals its possible association with spatial positioning of chromosomes

2022-06-17

Abstract excerpt

Loss of heterozygosity (LOH) is a genetic alteration that results from the loss of one allele at a heterozygous locus. Some LOH events are generated by mitotic homologous recombination after monoallelic defection, then the novel homozygous locus has two copies of the normal counterpart allele. This phenomenon can serve as a source of genome diversity and is associated with various diseases. To clarify the nature o...

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Literature Corpus work: 42c0814d-e6bd-5062-a89d-5d581079a03c
DOI: 10.1101/2022.06.14.496055

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