Article

Beyond Exons: Linking Noncoding Heritability and Polygenicity across Complex Human Traits and Disorders

2026-04-03

Abstract excerpt

The genetic architecture of complex traits spans a continuum of polygenicity, yet it remains unclear how differences in polygenicity relate to the functional localization of SNP heritability across the genome. We use a MiXeR-based framework to partition heritability across exonic, intronic, and intergenic regions for 34 traits and introduce a likelihood-based annotation contribution score that quantifies annotatio...

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Literature Corpus work: 8ad7b893-2071-52a4-9d0c-7e18d16de631
DOI: 10.64898/2026.04.01.715766

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