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Article

DNA replication initiation drives focal mutagenesis and rearrangements in human cancers.

Nature communications - 30 Dec 2024

Murat Pierre, Guilbaud Guillaume, Sale Julian E

Abstract excerpt

The rate and pattern of mutagenesis in cancer genomes is significantly influenced by DNA accessibility and active biological processes. Here we show that efficient sites of replication initiation drive and modulate specific mutational processes in cancer. Sites of replication initiation impede nucleotide excision repair in melanoma and are off-targets for activation-induced deaminase (AICDA) activity in...

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Identifiers

PMID: 39738026
DOI: 10.1038/s41467-024-55148-3
PMCID: PMC11685606

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