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Article

Disruption of deoxyribonucleotide triphosphate biosynthesis leads to RAS proto-oncogene activation and perturbation of mitochondrial metabolism.

The Journal of biological chemistry - 1 Feb 2025

Suspène Rodolphe, Raymond Kyle A, Guardado-Calvo Pablo, Dairou Julien, Bonhomme Frédéric, Bonenfant Christine, Guyetant Serge, Lecomte Thierry, Pagès Jean-Christophe, Vartanian Jean-Pierre

Abstract excerpt

Perturbation of the deoxyribonucleotide triphosphate (dNTP) pool is recognized for contributing to the mutagenic processes involved in oncogenesis. The RAS gene family encodes well-characterized oncoproteins whose structure and function are among the most frequently altered in several cancers. In this work, we show that fluctuation of the dNTP pool induces CG → TA mutations across the whole genome, including RAS...

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Identifiers

PMID: 39722416
DOI: 10.1016/j.jbc.2024.108117
PMCID: PMC11791277

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