Diverse roles of nucleoside diphosphate kinase in genome stability and growth fitness.

doi:10.1007/s00294-020-01073-z

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Article

Diverse roles of nucleoside diphosphate kinase in genome stability and growth fitness.

Current genetics - 1 Aug 2020

Kapoor Indu, Varshney Umesh

Abstract excerpt

Nucleoside diphosphate kinase (NDK), a ubiquitous enzyme, catalyses reversible transfer of the γ phosphate from nucleoside triphosphates to nucleoside diphosphates and functions to maintain the pools of ribonucleotides and deoxyribonucleotides in the cell. As even a minor imbalance in the nucleotide pools can be mutagenic, NDK plays an antimutator role in maintaining genome integrity. However, the mechanism of...

Topics

Animals
Escherichia coli
Genomic Instability
Humans
Mutation
Nucleoside-Diphosphate Kinase
Pyruvate Kinase
Succinate-CoA Ligases
Uracil

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Open in PubMed

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PMID: 32249353
DOI: 10.1007/s00294-020-01073-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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