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Article

p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jul 2021

Li Gen, Wu Jun, Li Le, Jiang Peng

Abstract excerpt

Cancer cells acquire metabolic reprogramming to satisfy their high biogenetic demands, but little is known about how metabolic remodeling enables cancer cells to survive stress associated with genomic instability. Here, we show that the mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) is transcriptionally suppressed by p53, and its up-regulation by p53 inactivation leads to increased folate...

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Identifiers

PMID: 34244426
DOI: 10.1073/pnas.2019822118
PMCID: PMC8285905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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