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Article

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications.

Molecular cancer - 29 Sept 2015

Kohnken Rebecca, Kodigepalli Karthik M, Wu Li

Abstract excerpt

Regulation of intracellular deoxynucleoside triphosphate (dNTP) pool is critical to genomic stability and cancer development. Imbalanced dNTP pools can lead to enhanced mutagenesis and cell proliferation resulting in cancer development. Therapeutic agents that target dNTP synthesis and metabolism are commonly used in treatment of several types of cancer. Despite several studies, the molecular mechanisms that...

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Source

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Identifiers

PMID: 26416562
DOI: 10.1186/s12943-015-0446-6
PMCID: PMC4587406

Genes

SAMHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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