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Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances.

Mutation research - 28 Nov 2010

Rampazzo Chiara, Miazzi Cristina, Franzolin Elisa, Pontarin Giovanna, Ferraro Paola, Frangini Miriam, Reichard Peter, Bianchi Vera

Abstract excerpt

Deoxyribonucleoside triphosphates (dNTPs) are the precursors used by DNA polymerases for replication and repair of nuclear and mitochondrial DNA in animal cells. Accurate DNA synthesis requires adequate amounts of each dNTP and appropriately balanced dNTP pools. Total cellular pool sizes are in the range of 10-100pmoles of each dNTP/million cells during S phase, with mitochondrial pools representing at most 10%...

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Identifiers

PMID: 20561600
DOI: 10.1016/j.mrgentox.2010.06.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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