Article
Mutations induced at the hypoxanthine-guanine phosphoribosyltransferase locus of human T-lymphoblasts by perturbations of purine deoxyribonucleoside triphosphate pools.
Cancer research - 1 Aug 1990
Mattano S S, Palella T D, Mitchell B S
Abstract excerpt
Chronic perturbations of intracellular deoxyribonucleoside triphosphate (dNTP) pools have been associated with a mutator phenotype and increased mutation rates at several genetic loci. We have examined the specific effects of transient pharmacological purine dNTP pool perturbations on mutations i...
Topics
- Base Sequence
- Cell Line
- Deoxyadenosines
- Deoxyguanosine
- Deoxyribonucleotides
- Enzyme Induction
- Gene Amplification
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Purine Nucleotides
- T-Lymphocytes
- Tumor Cells, Cultured