Article
International Commission for Protection Against Environmental Mutagens and Carcinogens. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability.
Mutation research - 1 Aug 1994
Kunz B A, Kohalmi S E, Kunkel T A, Mathews C K, McIntosh E M, Reidy J A
Abstract excerpt
DNA precursor pool imbalances can elicit a variety of genetic effects and modulate the genotoxicity of certain DNA-damaging agents. These and other observations indicate that the control of DNA precursor concentrations is essential for the maintenance of genetic stability, and suggest that factors which offset this control may contribute to environmental mutagenesis and carcinogenesis. In this article, we review...
Topics
- Animals
- Bacteria
- Cell Cycle
- DNA Damage
- DNA Replication
- Deoxyribonucleosides
- Deoxyribonucleotides
- Fungi
- Homeostasis
- Humans
- Mutation