Article

Quantitation, base identity and distribution of stably incorporated ribonucleotides in nuclear and mitochondrial DNA from murine tissues

2022-03-22

Abstract excerpt

Ribonucleotides are estimated to be the most common non-canonical nucleotides transiently incorporated in DNA. Their presence or failure of their removal can affect genome stability and mutations in factors involved in dNTP pool maintenance or ribonucleotide removal can cause Aicardi-Goutières syndrome or promote certain human cancers. Here, we have mapped and quantitated ribonucleotides genome-wide, in nine tissu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b03bd1c0-661c-50b7-a457-53146c67322f
DOI: 10.1101/2022.03.20.485043

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantitation, base identity and distribution of stably incorporated ribonucleotides in nuclear and mitochondrial DNA from murine tissuesDOI 10.1101/2022.03.20.485043Read

Human ribomes reveal DNA-embedded ribonucleotides as a new type of epigenetic markSemantic proximity Read

rNMPID: a database for riboNucleoside Mono-Phosphates In DNASemantic proximity Read

RNA-DNA Differences: Redox Stress, Genomic Instability, and Implications for Human HealthSemantic proximity Read

Mitochondrial Epitranscriptomics: The Role of RNA Modifications in Cellular Energy Regulation and AgingSemantic proximity Read

Ribogenomics: the science and knowledge of RNA.Semantic proximity Read

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in miceSemantic proximity Read

Dominant Formation of DNA:RNA Hybrid G-Quadruplexes in the Genomes of Living Human and Mouse CellsSemantic proximity Read

Metabolism of epigenetic ribonucleosides leads to nucleolar stress and cytotoxicitySemantic proximity Read

Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolutionSemantic proximity Read

Triplex and other DNA motifs show motif-specific associations with mitochondrial DNA deletions and species lifespan.Semantic proximity Read

TRMT2B is responsible for both tRNA and rRNA m 5 U-methylation in human mitochondriaSemantic proximity Read

Distinct features of ribonucleotides within genomic DNA in Aicardi-Goutières syndrome (AGS)-ortholog mutants of Saccharomyces cerevisiaeSemantic proximity Read