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Extracellular Matrix Stiffness Alters TRPV4 Regulation in Chondrocytes

2021-09-14

Abstract excerpt

During the progression of osteoarthritis (OA), degradation of the extracellular matrix alters the biomechanical properties of cartilage, especially the compressive modulus. The mechanosensitive ion channel transient receptor potential vanilloid 4 (TRPV4) is required for chondrocyte mechanotransduction However, how OA-mediated cartilage degradation influences TRPV4 signaling remains unknown. To determine if ATDC5 c...

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Identifiers and source

Literature Corpus work
07c72565-d348-5158-bd5c-5b9866eed743
DOI
10.1101/2021.09.14.460172
Open publication

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Extracellular Matrix Stiffness Alters TRPV4 Regulation in ChondrocytesDOI 10.1101/2021.09.14.460172
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