Hippo Signaling Modulates the Inflammatory Response of Chondrocytes to Mechanical Compressive Loading

Abstract excerpt

Knee osteoarthritis (KOA) is a degenerative disease resulting from mechanical overload, where direct physical impacts on chondrocytes play a crucial role in disease development by inducing inflammation and extracellular matrix degradation. However, the signaling cascades that sense these physical impacts and induce the pathogenic transcriptional programs of KOA remain to be defined, which hinders the identificatio...

Topics

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• Bone Metabolism and Diseases
• Cells, Cultured
• Chondrocytes
• Extracellular Matrix
• Inflammatory mediators and NSAID effects
• NF-κB Signaling Pathways
• NF-kappa B
• Osteoarthritis Treatment and Mechanisms

Identifiers and source

Literature Corpus work

d7d2b44d-ea35-551f-bbb6-102f3f895607

DOI

10.1101/2023.06.09.544419