Article

Modelling Osteoarthritis pathogenesis through Mechanical Loading in an Osteochondral Unit-on-Chip

2023-08-31

Abstract excerpt

A cure for osteoarthritis (OA), the most prevalent musculoskeletal disease, remains an unmet need. Investigating the molecular and cellular processes leading to OA is challenged by the absence of human models that capture the complex interplay among different tissues in the joint under pathophysiological mechanical loading. In this study, we have engineered an OsteoChondral Unit (OCU)-on-chip system where composit...

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Literature Corpus work: 4b3116cf-ad95-56db-a579-b977bc1e9296
DOI: 10.1101/2023.08.29.555292

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