Article

Mechanical loading rescues mechanoresponsiveness in a human osteoarthritis explant model despite Wnt activation

2023-11-27

Abstract excerpt

<h4>Objectives</h4> Optimizing rehabilitation strategies for osteoarthritis necessitates a comprehensive understanding of chondrocytes’ mechanoresponse in both health and disease, especially in the context of the interplay between loading and key pathways involved in osteoarthritis development, like canonical Wnt signaling. This study aims to elucidate the role of Wnt signaling in the mechanoresponsiveness of hea...

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Literature Corpus work: 91aa2db7-9aab-5da5-8e95-ef9d788390f0
DOI: 10.1101/2023.11.27.568718

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