Article

NAMPT activity plays a key role in driving autoimmune processes that mediate beta-cell death and type 1 diabetes development in mice

2025-07-01

Abstract excerpt

<title>Abstract</title> <p> Type 1 diabetes (T1D) is characterised by destruction of pancreatic beta-cells by islet-infiltrating cytotoxic lymphocytes, and elevated intra-islet secretion of pro-inflammatory cytokines. However, the underlying pathophysiological mechanisms remain incompletely understood. We hypothesised that abnormal elevation of islet NAD, via activation of NAMPT, plays a key role in driving isle...

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Literature Corpus work: 00909175-9004-571e-8eba-bc5a9b5c4312
DOI: 10.21203/rs.3.rs-6905832/v1

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