Article

NAMPT activity plays a key role in driving autoimmune processes that characterise type 1 diabetes development in mice

2025-01-15

Abstract excerpt

Type 1 diabetes (T1D) is characterised by destruction of pancreatic beta cells by islet-infiltrating cytotoxic lymphocytes, and elevated intra-islet secretion of pro-inflammatory cytokines. However, the underlying pathophysiological mechanisms remain incompletely understood. We hypothesised that abnormal elevation of islet NAD, via activation of NAMPT, plays a key role in driving islet autoimmune processes in T1D....

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Literature Corpus work: a0ed9860-ed27-5bbe-91ef-311406251e69
DOI: 10.1101/2025.01.14.632985

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