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Proliferating CLL cells express high levels of CXCR4 and CD5

1 Dec 2024

Abstract excerpt

Abstract Chronic lymphocytic leukemia (CLL) is an incurable progressive malignancy of CD5 + B cells with a birth rate between 0.1% and 1% of the entire clone per day. However, the phenotype and functional characteristics of proliferating CLL cells remain incompletely understood. Here, we stained peripheral blood CLL cells for ki67 and DNA content and found that CLL cells in G1‐phase have a CXCR4 lo CD5 hi...

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PMID: 39691453
DOI: 10.1002/hem3.70064

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