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Article

CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness.

Leukemia - 1 Oct 2021

Lewis Richard, Maurer H Carlo, Singh Nikita, Gonzalez-Menendez Irene, Wirth Matthias, Schick Markus, Zhang Le, Isaakidis Konstandina, Scherger Anna Katharina, Schulze Veronika, Lu Junyan, Zenz Thorsten, Steiger Katja, Rad Roland, Quintanilla-Martinez Leticia, Espeli Marion, Balabanian Karl, Keller Ulrich, Habringer Stefan

Abstract excerpt

Aberrant CXCR4 activity has been implicated in lymphoma pathogenesis, disease progression, and resistance to therapies. Using a mouse model with a gain-of-function CXCR4 mutation (CXCR4C1013G) that hyperactivates CXCR4 signaling, we identified CXCR4 as a crucial activator of multiple key oncogenic pathways. CXCR4 hyperactivation resulted in an expansion of transitional B1 lymphocytes, which represent the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Identifiers

PMID: 34363012
DOI: 10.1038/s41375-021-01376-1
PMCID: PMC8478649

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