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Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration

2 Jun 2016

Abstract excerpt

Several lines of evidence suggest that homing of tumor cells to lymphoid tissue contributes to disease progression in chronic lymphocytic leukemia (CLL). Here, we demonstrate that lymph node (LN)-derived CLL cells possess a distinct phenotype, and exhibit enhanced capacity for T-cell activation and superior immune synapse formation when compared with paired peripheral blood (PB) samples. LN-derived CLL cells...

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PMID: 27252234
DOI: 10.1182/blood-2016-01-683128

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