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Article

B-Cell Clones as Early Markers for Chronic Lymphocytic Leukemia

11 Feb 2009

Abstract excerpt

BACKGROUND: Otherwise healthy persons with a small number of B-cell clones circulating in the peripheral blood have been designated as having monoclonal B-cell lymphocytosis (MBL). Hospital-based series indicate an excess risk of progression from MBL to chronic lymphocytic leukemia (CLL). In this prospective cohort study, we tested the hypothesis that CLL is always preceded by MBL. METHODS: Among 77,469 healthy...

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PMID: 19213679
DOI: 10.1056/nejmoa0806122

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