Back to search

Article

A heterogeneous pool of tumor precursor cells with self-replenishing and tumor-originating properties in early pathogenesis of Chronic Lymphocytic Leukemia

2022-05-04

Abstract excerpt

Intratumor heterogeneity (ITH) refers to the coexistence of distinct cancer cell subpopulations within a single tumor, each with unique molecular and functional properties. Understanding the dynamics and evolution of ITH is crucial for predicting tumor progression and the development of therapy resistance. Here, we conducted a comprehensive investigation of ITH in Chronic Lymphocytic Leukemia (CLL) and identified...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
377ff0d7-16f7-50f8-9b57-f74da5ac39f1
DOI
10.1101/2022.05.04.490383
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A heterogeneous pool of tumor precursor cells with self-replenishing and tumor-originating properties in early pathogenesis of Chronic Lymphocytic LeukemiaDOI 10.1101/2022.05.04.490383
Clonal Evolution of High-Risk Chronic Lymphocytic Leukemia: A Contemporary PerspectiveSemantic proximity
Molecular pathogenesis of CLL and its evolution.Semantic proximity
The early evolution of chronic clonal lymphocytosisSemantic proximity
Chronic lymphocytic leukemia and mantle cell lymphoma: crossroads of genetic and microenvironment interactions.Semantic proximity
Cellular origin and pathophysiology of chronic lymphocytic leukemia.Semantic proximity
The molecular map of CLL and Richter's syndromeSemantic proximity
SOHO State of the Art Updates and Next Questions: Clonal Evolution in Chronic Lymphocytic Leukemia.Semantic proximity
Clonal evolution in chronic lymphocytic leukemia: impact of subclonality on disease progression.Semantic proximity
The immune microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemiaSemantic proximity
Pathogenesis of chronic lymphocytic leukemia and the development of novel therapeutic strategies.Semantic proximity
Pathophysiology of chronic lymphocytic leukemia and human B1 cell development.Semantic proximity
Chronic lymphocytic leukemia: from molecular pathogenesis to novel therapeutic strategiesSemantic proximity
Select a neighboring publication to make it the new centre.