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Article

Establishment and Characterization of PCL12, a Novel CD5+ Chronic Lymphocytic Leukaemia Cell Line.

PloS one - 1 Jan 2015

Agathangelidis Andreas, Scarfò Lydia, Barbaglio Federica, Apollonio Benedetta, Bertilaccio Maria Teresa Sabrina, Ranghetti Pamela, Ponzoni Maurilio, Leone Gabriella, De Pascali Valeria, Pecciarini Lorenza, Ghia Paolo, Caligaris-Cappio Federico, Scielzo Cristina

Abstract excerpt

Immortalized cell lines representative of chronic lymphocytic leukemia (CLL) can assist in understanding disease pathogenesis and testing new therapeutic agents. At present, very few representative cell lines are available. We here describe the characterization of a new cell line (PCL12) that grew spontaneously from the peripheral blood (PB) of a CLL patient with progressive disease and EBV infection. The CLL...

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Share to CD5 Antigens
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Neoplasm Transplantation

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Share to ZAP-70 Protein-Tyrosine Kinase

Source

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Identifiers

PMID: 26110819
DOI: 10.1371/journal.pone.0130195
PMCID: PMC4481539

Genes

IGH
LYN
ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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