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Article

Association of peripheral CD4+ CXCR5+ T cells with chronic lymphocytic leukemia.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2013

Cha Zhanshan, Zang Yan, Guo Huijun, Rechlic James R, Olasnova Lindsay M, Gu Haihui, Tu Xiaohua, Song Haihan, Qian Baohua

Abstract excerpt

Accumulating evidences indicate that immune dysregulation plays a key role in both lymphomagenesis and patient outcome of chronic lymphocytic leukemia (CLL). Peripheral blood CD4+ CXCR5+ T cells, known as circulating follicular helper T cells (Tfh), can induce B cell activation and production of specific antibody responses. The aim of the study was to investigate changes of circulating Tfh in CLL. Tfh and it...

Read the complete abstract on PubMed

Topics

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Share to CD4 Antigens
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Receptors, CXCR3

Share to T-Lymphocytes, Helper-Inducer

Source

Identifiers

PMID: 23807677
DOI: 10.1007/s13277-013-0937-2

Genes

CXCR5
CCR6
CXCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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