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Detection of single nucleotide variants in the mitochondrial genome of healthy mice and humans.

Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis - 1 Jan 2025

Varela-Echavarría Alfredo, Contreras-Ramírez Kenya L, Lozano-Flores Carlos, Hernández-Rosales Maribel

Abstract excerpt

Single nucleotide mutations in the mitochondrial genome are linked to aging in humans, primates, and rodents and cause neuromuscular diseases in humans. Load of mitochondrial variants in healthy tissues, however, is little known. Employing an unbiased detection method with no prior enzymatic amplification, we observed that the mitochondrial genome of embryonic, adult, and aged mouse brain from two different...

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PMID: 39668504
DOI: 10.1080/24701394.2024.2439421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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