Article
Pervasive within-Mitochondrion Single-Nucleotide Variant Heteroplasmy as Revealed by Single-Mitochondrion Sequencing.
Cell reports - 5 Dec 2017
Morris Jacqueline, Na Young-Ji, Zhu Hua, Lee Jae-Hee, Giang Hoa, Ulyanova Alexandra V, Baltuch Gordon H, Brem Steven, Chen H Isaac, Kung David K, Lucas Timothy H, O'Rourke Donald M, Wolf John A, Grady M Sean, Sul Jai-Yoon, Kim Junhyong, Eberwine James
Abstract excerpt
A number of mitochondrial diseases arise from single-nucleotide variant (SNV) accumulation in multiple mitochondria. Here, we present a method for identification of variants present at the single-mitochondrion level in individual mouse and human neuronal cells, allowing for extremely high-resolution study of mitochondrial mutation dynamics. We identified extensive heteroplasmy between individual mitochondrion,...
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