Article
Advanced age increases frequencies of de novo mitochondrial mutations in macaque oocytes and somatic tissues.
Proceedings of the National Academy of Sciences of the United States of America - 12 Apr 2022
Arbeithuber Barbara, Cremona Marzia A, Hester James, Barrett Alison, Higgins Bonnie, Anthony Kate, Chiaromonte Francesca, Diaz Francisco J, Makova Kateryna D
Abstract excerpt
Mutations in mitochondrial DNA (mtDNA) contribute to multiple diseases. However, how new mtDNA mutations arise and accumulate with age remains understudied because of the high error rates of current sequencing technologies. Duplex sequencing reduces error rates by several orders of magnitude via independently tagging and analyzing each of the two template DNA strands. Here, using duplex sequencing, we obtained...
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