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Article

Mapping functional elements of the DNA damage response through base editor screens.

Cell reports - 24 Dec 2024

Pan Qian, Zhang Zhixuan, Xiong Yangfang, Bao Ying, Chen Tianxin, Xu Ping, Liu Zhiheng, Ma Huazheng, Yu Ying, Zhou Zhuo, Wei Wensheng

Abstract excerpt

Maintaining genomic stability is vital for cellular equilibrium. In this study, we combined CRISPR-mediated base editing with pooled screening technologies to identify numerous mutations in lysine residues and protein-coding genes. The loss of these lysine residues and genes resulted in either sensitivity or resistance to DNA-damaging agents. Among the identified variants, we characterized both loss-of-function...

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Identifiers

PMID: 39661519
DOI: 10.1016/j.celrep.2024.115047

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