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Article

Anxio-depressive phenotype and impaired memory in mice with a conditional knockout of brain-derived neurotrophic factor in endothelial cells.

American journal of physiology. Cell physiology - 1 Jan 2025

Quirié Aurore, Mor Damien, Méloux Alexandre, Etievant Adeline, Garnier Philippe, Totoson Perle, Wirtz Julien, Prigent-Tessier Anne, Marie Christine, Demougeot Céline

Abstract excerpt

The present study investigated the role of endothelial brain-derived neurotrophic factor (BDNF) in cognition. Male adult mice with a selective knockout of BDNF in endothelial cells (BDNFECKO) and their wild-type (WT) littermates were subjected to tests for detection of anxiety- and depression-like behaviors and impaired recognition memory. Neuronal activity and synaptogenesis were assessed from hippocampal levels...

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Source

Identifiers

PMID: 39652745
DOI: 10.1152/ajpcell.00699.2024

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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