Article
Elastase-2 Knockout Mice Display Anxiogenic- and Antidepressant-Like Phenotype: Putative Role for BDNF Metabolism in Prefrontal Cortex.
Molecular neurobiology - 1 Aug 2018
Diniz C R A F, Becari C, Lesnikova A, Biojone C, Salgado M C O, Salgado H C, Resstel L B M, Guimarães F S, Castrén E, Casarotto P C, Joca S R L
Abstract excerpt
Several pieces of evidence indicate that elastase-2 (ELA2; chymotrypsin-like ELA2) is an alternative pathway to the generation of angiotensin II (ANGII). Elastase-2 knockout mice (ELA2KO) exhibit alterations in the arterial blood pressure and heart rate. However, there is no data on the behavioral consequences of ELA2 deletion. In this study, we addressed this question, submitting ELA2KO and wild-type (WT) mice...
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