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Article

Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness.

American journal of respiratory and critical care medicine - 1 Mar 2025

van Amstel Rombout B E, Bartek Brian, Vlaar Alexander P J, Gay Elizabeth, van Vught Lonneke A, Cremer Olaf L, Van der Poll Tom, Shapiro Nathan I, Matthay Michael A, Calfee Carolyn S, Sinha Pratik, Bos Lieuwe D J

Abstract excerpt

Rationale: Systemic molecular phenotypes of critical illness are prognostically informative, yet their temporal kinetics and implications of changing phenotypes remain incompletely understood. Objectives: To determine the temporal nature of the Hyperinflammatory and Hypoinflammatory phenotypes and assess the impact of transition between the phenotypes on mortality. Methods: We used data from one prospective...

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Identifiers

PMID: 39642348
DOI: 10.1164/rccm.202406-1241OC
PMCID: PMC11936145

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