Article
Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes.
American journal of respiratory and critical care medicine - 1 Apr 2024
Neyton Lucile P A, Sinha Pratik, Sarma Aartik, Mick Eran, Kalantar Katrina, Chen Stephanie, Wu Nelson, Delucchi Kevin, Zhuo Hanjing, Bos Lieuwe D J, Jauregui Alejandra, Gomez Antonio, Hendrickson Carolyn M, Kangelaris Kirsten N, Leligdowicz Aleksandra, Liu Kathleen D, Matthay Michael A, Langelier Charles R, Calfee Carolyn S
Abstract excerpt
Rationale: Two molecular phenotypes of sepsis and acute respiratory distress syndrome, termed hyperinflammatory and hypoinflammatory, have been consistently identified by latent class analysis in numerous cohorts, with widely divergent clinical outcomes and differential responses to some treatments; however, the key biological differences between these phenotypes remain poorly understood.Objectives: We used host...
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