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Article

Temporal stability of phenotypes of acute respiratory distress syndrome: clinical implications for early corticosteroid therapy and mortality.

Intensive care medicine - 1 Oct 2025

Pensier Joris, Fosset Maxime, Paschold Béla-Simon, von Wedel Dario, Redaelli Simone, Braeuer Ben L P, Novack Victor, Balzer Felix, Jung Boris, Amato Marcelo B P, Jaber Samir, Talmor Daniel, Baedorf-Kassis Elias, Schaefer Maximilian S

Abstract excerpt

PURPOSE: Inflammatory phenotypes of acute respiratory distress syndrome (ARDS) can predict patient outcomes and potentially response to treatment. The aim was to assess whether inflammatory phenotypes can be characterized over time using clinical surrogate data and used to guide therapy with corticosteroids. METHODS: Individual patient data and biomarkers from six multicenter randomized controlled trials...

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PMID: 40839098
DOI: 10.1007/s00134-025-08089-4

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