Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.

doi:10.1016/S2213-2600(23)00237-0

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Article

Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.

The Lancet. Respiratory medicine - 1 Nov 2023

Sinha Pratik, Kerchberger V Eric, Willmore Andrew, Chambers Julia, Zhuo Hanjing, Abbott Jason, Jones Chayse, Wickersham Nancy, Wu Nelson, Neyton Lucile, Langelier Charles R, Mick Eran, He June, Jauregui Alejandra, Churpek Matthew M, Gomez Antonio D, Hendrickson Carolyn M, Kangelaris Kirsten N, Sarma Aartik, Leligdowicz Aleksandra, Delucchi Kevin L, Liu Kathleen D, Russell James A, Matthay Michael A, Walley Keith R, Ware Lorraine B, Calfee Carolyn S

Abstract excerpt

BACKGROUND: In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular phenotypes (hypoinflammatory and hyperinflammatory) have consistently been identified, with divergent outcomes and treatment responses. In this study, we sought to derive molecular phenotypes in critically ill adults with sepsis,...

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PMID: 37633303
DOI: 10.1016/S2213-2600(23)00237-0
PMCID: PMC10841178

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