Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study.

doi:10.1016/S2213-2600(26)00040-8

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Article

Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study.

The Lancet. Respiratory medicine - 1 Jul 2026

Reddy Kiran, Sinha Pratik, Antcliffe David B, McDowell Clíona, Bradley Pauline A, Black Laura, Murphy Lynn, Barbaras Judit, Conlon John, Camporota Luigi, Ostermann Marlies, Hopkins Phillip, Szakmany Tamas, Cherian Shiney, Welters Ingeborg, Brealey David, Parekh Dhruv, Rostron Anthony J, Bos Lieuwe D J, Nichol Alistair, Shankar-Hari Manu, Gordon Anthony C, Delucchi Kevin, O'Kane Cecilia M, Matthay Michael A, Calfee Carolyn S, McAuley Daniel F

Abstract excerpt

BACKGROUND: Acute respiratory distress syndrome (ARDS) is a clinically defined, biologically heterogeneous condition with no proven disease-modifying therapies. Retrospective analyses have identified two biologically distinct subphenotypes (hyperinflammatory and hypoinflammatory) of ARDS, with differing outcomes and responses to therapy. Rapid identification of these subphenotypes in an actionable timeframe has...

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PMID: 41887245
DOI: 10.1016/S2213-2600(26)00040-8

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