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Article

Patient stratification using plasma cytokines and their regulators in sepsis: relationship to outcomes, treatment effect and leucocyte transcriptomic subphenotypes.

Thorax - 20 May 2024

Antcliffe David Benjamin, Mi Yuxin, Santhakumaran Shalini, Burnham Katie L, Prevost A Toby, Ward Josie K, Marshall Timothy J, Bradley Claire, Al-Beidh Farah, Hutton Paula, McKechnie Stuart, Davenport Emma E, Hinds Charles J, O'Kane Cecilia M, McAuley Daniel Francis, Shankar-Hari Manu, Gordon Anthony C, Knight Julian C

Abstract excerpt

RATIONALE: Heterogeneity of the host response within sepsis, acute respiratory distress syndrome (ARDS) and more widely critical illness, limits discovery and targeting of immunomodulatory therapies. Clustering approaches using clinical and circulating biomarkers have defined hyper-inflammatory and hypo-inflammatory subphenotypes in ARDS associated with differential treatment response. It is unknown if similar...

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Identifiers

PMID: 38471792
DOI: 10.1136/thorax-2023-220538
PMCID: PMC11137467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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