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Temporal stability of inflammatory subphenotypes of acute respiratory distress syndrome: 28-day insights from the ICAR trial.

Anaesthesia, critical care & pain medicine - 1 Sept 2025

Renard Triché Laurent, Fosset Maxime, Jabaudon Matthieu, Futier Emmanuel, Lucas Bruno, Latroche Claire, Paschold Béla-Simon, Baedorf-Kassis Elias, Sharshar Tarek, Schaefer Maximilian S, Jung Boris, Mazeraud Aurélien, Pensier Joris

Abstract excerpt

BACKGROUND: International guidelines have emphasized the necessity of evaluating the temporal stability of acute respiratory distress syndrome (ARDS) subphenotypes. This study aimed to assess the temporal stability of subphenotypes of ARDS over 28 days. METHODS: A reanalysis of a randomized trial was conducted, including patients with COVID-19-related moderate-to-severe ARDS across 43 centers. A K-means...

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PMID: 40436270
DOI: 10.1016/j.accpm.2025.101559

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