Article
Molecular phenotypes of critical illness confer prognostic and biological enrichment in sub-Saharan Africa: a prospective cohort study from Uganda.
Thorax - 17 Feb 2025
Cummings Matthew J, Lutwama Julius J, Tomoiaga Alin S, Owor Nicholas, Lu Xuan, Ross Jesse E, Muwanga Moses, Nsereko Christopher, Nayiga Irene, Nie Kai, Kayiwa John, Che Xiaoyu, Wayengera Misaki, Kim-Schulze Seunghee, Lipkin W Ian, O'Donnell Max R, Bakamutumaho Barnabas
Abstract excerpt
The generalisability of critical illness molecular phenotypes to low- and middle-income countries (LMICs) is unknown. We show that molecular phenotypes derived in high-income countries (hyperinflammatory and hypoinflammatory, reactive and uninflamed) stratify sepsis patients in Uganda by physiological severity, mortality risk and dysregulation of key pathobiological domains. A classifier model including data...
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