Article
Large-scale proteomic profiling identifies distinct inflammatory phenotypes in acute respiratory distress syndrome: a multicentre, prospective cohort study.
The European respiratory journal - 1 Feb 2026
Lin Mengna, Xu Feixiang, Deng Yiyu, Wei Ying, Shi Feng, Xie Yun, Xie Cuiying, Chen Chen, Song Jianfeng, Shen Yao, Lin Yiyan, Ding Hailin, Zhou Yannan, Lu Su, Chen Yumei, Lan Lulu, Zhao Wenxin, Zhu Jing, Kuang Zhongshu, Pang Wei, Que Sijin, Fang Xiaoyu, Ji Ran, Dong Chenyang, Zhang Jiancheng, Liu Qi, Zhang Zhaocai, Gao Chengjin, Chen Lei, Song Yuanlin, Zhan Liying, Huang Lihong, Wu Xueling, Wang Ruilan, Song Zhenju
Abstract excerpt
BACKGROUND: Host responses during acute respiratory distress syndrome are highly heterogeneous, contributing to inconsistent therapeutic outcomes. Proteome-based phenotyping may identify biologically and clinically distinct phenotypes to guide precision therapy. METHODS: In this multicentre cohort study, we used latent class analysis of targeted serum proteomics to identify acute respiratory distress syndrome...
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